IUBMB Enzyme Nomenclature

EC 2.4.99.10

Accepted name: neolactotetraosylceramide α-2,3-sialyltransferase

Reaction: CMP-N-acetylneuraminate + β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-D-glucosyl-(1↔1)-ceramide = CMP + α-N-acetylneuraminyl-(2→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-D-glucosyl-(1↔1)-ceramide

Glossary: neolactotetraosylceramide = β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-D-glucosyl-(1↔1)-ceramide

Other name(s): sialyltransferase; cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase; sialyltransferase 3; SAT-3

Systematic name: CMP-N-acetylneuraminate:neolactotetraosylceramide α-2,3-sialyltransferase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 83745-06-6

References:

1. Basu, M., Basu, S., Stoffyn, A. and Stoffyn, P. Biosynthesis in vitro of sialyl(α2-3)neolactotetraosylceramide by a sialyltransferase from embryonic chicken brain. J. Biol. Chem. 257 (1982) 12765-12769. [PMID: 7130178]

[EC 2.4.99.10 created 1986]


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