EC 2.4.99.2

Reaction: CMP-N-acetylneuraminate + D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-(1↔1)-ceramide = CMP + N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-(1↔1)-ceramide

For diagram of reaction click here.

Other name(s): CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase; CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl(1↔1)ceramide N-acetylneuraminyltransferase

Systematic name: CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-(1↔1)-ceramide N-acetylneuraminyltransferase

Comments: May be identical with EC 2.4.99.4 β-galactoside α-2,3-sialyltransferase.

Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 60202-12-2

References:

1. Rearick, J.I., Sadler, J.E., Paulson, J.C. and Hill, R.L. Enzymatic characterization of β D-galactoside α23 sialyltransferase from porcine submaxillary gland. J. Biol. Chem. 254 (1979) 4444-4451. [PMID: 438198]

2. Yip, M.C.M. The enzymic synthesis of disialoganglioside: rat brain cytidine-5'-monophospho-N-acetylneuraminic acid: monosialoganglioside (GM₁) sialyltransferase. Biochim. Biophys. Acta 306 (1973) 298-306. [PMID: 4351506]