IUBMB Enzyme Nomenclature

EC 2.4.99.3

Accepted name: α-N-acetylgalactosaminide α-2,6-sialyltransferase

Reaction: CMP-N-acetylneuraminate + glycano-(1→3)-(N-acetyl-α-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2→6)-α-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein

Systematic name: CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-α-D-galactosaminyl)-glycoprotein α-2,6-N-acetylneuraminyltransferase

Comments: α-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 71124-50-0

References:

1. Sadler, J.E., Rearick, J.I. and Hill, R.L. Purification to homogeneity and enzymatic characterization of an α-N-acetylgalactosaminide α2[arrow right]6 sialyltransferase from porcine submaxillary glands. J. Biol. Chem. 254 (1979) 5934-5941. [PMID: 447688]

[EC 2.4.99.3 created 1984, modified 1986]


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