IUBMB Enzyme Nomenclature

EC 2.4.99.6

Accepted name: N-acetyllactosaminide α-2,3-sialyltransferase

Reaction: CMP-N-acetylneuraminate + β-D-galactosyl-(1→4)-N-acetyl-D-glucosaminyl-glycoprotein = CMP + α-N-acetylneuraminyl-(2→3)-β-D-galactosyl-(1→4)-N-acetyl-D-glucosaminyl-glycoprotein

Other name(s): sialyltransferase; cytidine monophosphoacetylneuraminate-β-galactosyl(1[arrow right]4)acetylglucosaminide α2[arrow right]3-sialyltransferase; α2[arrow right]3 sialyltransferase

Systematic name: CMP-N-acetylneuraminate:β-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein α-2,3-N-acetylneuraminyltransferase

Comments: Acts on β-D-galactosyl-1,4-N-acetyl-D-glucosaminyl termini on glycoprotein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 77537-85-0

References:

1. Van den Eijnden, D.H. and Schiphorst, W.E.C.M. Detection of β-galactosyl(1[arrow right]4)N-acetylglucosaminide α(2[arrow right]3)-sialyltransferase activity in fetal calf liver and other tissues. J. Biol. Chem. 256 (1981) 3159-3162. [PMID: 7204397]

[EC 2.4.99.6 created 1984, modified 1986]


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