Reaction: S-adenosylmethioninamine + putrescine = S-methyl-5'-thioadenosine + spermidine
For diagram of reaction click here.
Glossary: spermidine
spermine
Other name(s): aminopropyltransferase; putrescine aminopropyltransferase; spermidine synthetase; SpeE
Systematic name: S-adenosylmethioninamine:putrescine 3-aminopropyltransferase
Comments: This enzyme is not identical with EC 2.5.1.22, spermine synthase. The mammalian enzyme is highly specific but the bacterial enzyme can use other acceptors and can synthesize spermine.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37277-82-0
References:
1. Hannonen, P., Janne, J. and Raina, A. Partial purification and characterization of spermine synthase from rat brain. Biochim. Biophys. Acta 289 (1972) 225-231. [PMID: 4564056]
2. Pegg, A.E., Shuttleworth, K. and Hibasami, H. Specificity of mammalian spermidine synthase and spermine synthase. Biochem. J. 197 (1981) 315-320. [PMID: 6798961]
3. Tabor, C.W. Propylamine transferase (spermidine synthesis). Methods Enzymol. 5 (1962) 761-765.
4. Tabor, H. and Tabor, C.W. Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. Adv. Enzymol. Relat. Areas Mol. Biol. 36 (1972) 203-268. [PMID: 4628436]