Reaction: phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate
For diagram of reaction click here and mechanism click here.
Other name(s): N-acetylneuraminate 9-phosphate lyase; N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase; N-acetylneuraminate 9-phosphate synthetase; N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating); sialic acid 9-phosphate synthetase
Systematic name: phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Comments: Acts on N-glycoloyl and N-acetyl-derivatives.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9031-58-7
1. Roseman, S., Jourdian, G.W., Watson, D. and Rood, R. Enzymatic synthesis of sialic acid 9-phosphates. Proc. Natl. Acad. Sci. USA 47 (1961) 958-961.
2. Watson, D.R., Jourdian, G.W. and Roseman, S. The sialic acids. 8. Sialic acid 9-phosphate synthetase. J. Biol. Chem. 241 (1966) 5627-5636. [PMID: 5928202]
3. Nakata, D., Close, B.E., Colley, K.J., Matsuda, T. and Kitajima, K. Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity. Biochem. Biophys. Res. Commun. 273 (2000) 642-648. [PMID: 10873658]