IUBMB Enzyme Nomenclature


Accepted name: 1,4-dihydroxy-2-naphthoate polyprenyltransferase

Reaction: an all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO2

For diagram of reaction click here.

Glossary: menaquinone = vitamin K2

Systematic name: all-trans-polyprenyl diphosphate:1,4-dihydroxy-2-naphthoate polyprenyltransferase

Comments: This enzyme catalyses a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA). The bacterial enzyme is an inner membrane protein [1], with the C-terminus located in the periplasm [3]. It is highly specific for DHNA but not for a specific length of the prenyl chain [2].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Shineberg, B. and Young, I.G. Biosynthesis of bacterial menaquinones: the membrane-associated 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli. Biochemistry 15 (1976) 2754-2758. [PMID: 949474]

2. Saito, Y. and Ogura, K. Biosynthesis of menaquinones. Enzymatic prenylation of 1,4-dihydroxy-2-naphthoate by Micrococcus luteus membrane fractions. J. Biochem. 89 (1981) 1445-1452. [PMID: 7275947]

3. Suvarna, K., Stevenson, D., Meganathan, R. and Hudspeth, M.E. Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli. J. Bacteriol. 180 (1998) 2782-2787. [PMID: 9573170]

4. Daley, D.O., Rapp, M., Granseth, E., Melen, K., Drew, D. and von Heijne, G. Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 (2005) 1321-1323. [PMID: 15919996]

[EC created 2009]

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