IUBMB Enzyme Nomenclature

EC 2.5.1.94

Accepted name: adenosyl-chloride synthase

Reaction: S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine

Glossary: 5-deoxy-5-chloroadenosine = 5'-chloro-5'-deoxyadenosine

Other name(s): chlorinase; 5'-chloro-5'-deoxyadenosine synthase

Systematic name: S-adenosyl-L-methionine:chloride adenosyltransferase

Comments: This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Eustaquio, A.S., Pojer, F., Noel, J.P. and Moore, B.S. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat. Chem. Biol. 4 (2008) 69-74. [PMID: 18059261]

[EC 2.5.1.94 created 2011]


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