IUBMB Enzyme Nomenclature


Accepted name: leucine transaminase

Reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate

For diagram of reaction click here.

For diagram click here and another example (mechanism).

Other name(s): L-leucine aminotransferase; leucine 2-oxoglutarate transaminase; leucine aminotransferase; leucine-α-ketoglutarate transaminase

Systematic name: L-leucine:2-oxoglutarate aminotransferase

Comments: A pyridoxal-phosphate protein. This enzyme differs from EC, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9030-37-9


1. Aki, K., Ogawa, K. and Ichihara, A. Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver. Biochim. Biophys. Acta 159 (1968) 276-284. [PMID: 4968655]

2. Ikeda, T., Konishi, Y. and Ichihara, A. Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of rat liver mitochondria. Biochim. Biophys. Acta 445 (1976) 622-631. [PMID: 974100]

[EC created 1961, modified 1982]

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