IUBMB Enzyme Nomenclature


Accepted name: pyridoxine 5'-phosphate synthase

Reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O

For diagram, click here

Other name(s): pyridoxine 5-phosphate phospho lyase; PNP synthase; PdxJ

Systematic name: 1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing)

Comments: In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC (erythrose-4-phosphate dehydrogenase), EC (4-phosphoerythronate dehydrogenase), EC (phosphoserine transaminase), EC (4-hydroxythreonine-4-phosphate dehydrogenase), EC (pyridoxine 5'-phosphate synthase) and EC (with pyridoxine 5'-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate [3].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 230310-47-1


1. Garrido-Franco, M. Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond. Biochim. Biophys. Acta 1647 (2003) 92-97. [PMID: 12686115]

2. Garrido-Franco, M., Laber, B., Huber, R. and Clausen, T. Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis. J. Mol. Biol. 321 (2002) 601-612. [PMID: 12206776]

3. Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S. Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. FEBS Lett. 449 (1999) 45-48. [PMID: 10225425]

4. Franco, M.G., Laber, B., Huber, R. and Clausen, T. Structural basis for the function of pyridoxine 5'-phosphate synthase. Structure 9 (2001) 245-253. [PMID: 11286891]

[EC created 2006]

Return to EC 2.6.99 home page
Return to EC 2.6 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page