IUBMB Enzyme Nomenclature


Accepted name: inositol-trisphosphate 3-kinase

Reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

For diagram click here.

Other name(s): 1D-myo-inositol-trisphosphate 3-kinase; Ins(1,4,5)P3 3-kinase

Systematic name: ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase

Comments: Activated by Ca2+. Three isoforms have been shown to exist [3].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 106283-10-7


1. Hansen, C.A., Mah, S. and Williamson, J.R. Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver. J. Biol. Chem. 261 (1986) 8100-8103. [PMID: 3487541]

2. Irvine, R.F., Letcher, A.J., Heslop, J.P. and Berridge, M.J. The inositol tris/tetrakisphosphate pathway - demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues. Nature 320 (1986) 631-634. [PMID: 3010126]

3. Irvine, R.F. and Schell, M.J. Back in the water - the return of the inositol phosphates. Nat. Rev. Mol. Cell. Biol. 2 (2001) 327-338. [PMID: 11331907]

[EC created 1989, modified 2002]

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