IUBMB Enzyme Nomenclature


Accepted name: tetraacyldisaccharide 4'-kinase

Reaction: ATP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-β-D-glucosaminyl}-(1→6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl phosphate} = ADP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-β-D-glucosaminyl}-(1→6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl phosphate}

For diagram of reaction click here.

Other name(s): lipid-A 4'-kinase

Systematic name: ATP:2,2',3,3'-tetrakis[(3R)-3-hydroxytetradecanoyl]-β-D-glucosaminyl-(1→6)-α-D-glucosaminyl-phosphate 4'-O-phosphotransferase

Comments: Involved with EC (acyl-[acyl-carrier- protein]—UDP-N-acetylglucosamine O-acyltransferase) and EC (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 107309-06-8


1. Ray, B.L. and Raetz C.R.H. The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A. J. Biol. Chem. 262 (1987) 1122-1128. [PMID: 3027079]

[EC created 1990]

Return to EC 2.7.1 home page
Return to EC 2.7 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page