IUBMB Enzyme Nomenclature

EC 2.7.1.130

Accepted name: tetraacyldisaccharide 4'-kinase

Reaction: ATP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-β-D-glucosaminyl}-(1→6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl phosphate} = ADP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-β-D-glucosaminyl}-(1→6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl phosphate}

For diagram of reaction click here.

Other name(s): lipid-A 4'-kinase

Systematic name: ATP:2,2',3,3'-tetrakis[(3R)-3-hydroxytetradecanoyl]-β-D-glucosaminyl-(1→6)-α-D-glucosaminyl-phosphate 4'-O-phosphotransferase

Comments: Involved with EC 2.7.1.129 (acyl-[acyl-carrier- protein]—UDP-N-acetylglucosamine O-acyltransferase) and EC 2.4.1.182 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 107309-06-8

References:

1. Ray, B.L. and Raetz C.R.H. The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A. J. Biol. Chem. 262 (1987) 1122-1128. [PMID: 3027079]

[EC 2.7.1.130 created 1990]


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