IUBMB Enzyme Nomenclature


Accepted name: ketohexokinase

Reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate

Other name(s): ketohexokinase (phosphorylating)

Systematic name: ATP:D-fructose 1-phosphotransferase

Comments: D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates [4].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9030-50-6


1. Cori, G.T., Ochoa, S., Slein, M.W. and Cori, C.F. The metabolism of fructose in liver. Isolation of fructose-1-phosphate and inorganic pyrophosphate. Biochim. Biophys. Acta 7 (1951) 304-317.

2. Hers, H.G. La fructokinase du foie. Biochim. Biophys. Acta 8 (1952) 416-423.

3. Parks, R.E., Ben-Gershom, E. and Lardy, H.A. Liver fructokinase. J. Biol. Chem. 227 (1957) 231-242.

4. Raushel, F.M. and Cleland, W.W. Bovine liver fructokinase: purification and kinetic properties. Biochemistry 16 (1977) 2169-2175. [PMID: 193556]

[EC created 1961]

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