IUBMB Enzyme Nomenclature

EC 2.7.1.36

Accepted name: mevalonate kinase

Reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate

For reaction pathway click here.

Other name(s): mevalonate kinase (phosphorylating); mevalonate phosphokinase; mevalonic acid kinase; mevalonic kinase; mevalonate 5-phosphotransferase ; MVA kinase; ATP:mevalonate 5-phosphotransferase

Systematic name: ATP:(R)-mevalonate 5-phosphotransferase

Comments: CTP, GTP and UTP can also act as donors.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9026-52-2

References:

1. Hellig, H. and Popják, G. Studies on the biosynthesis of cholesterol. XIII. Phosphomevalonic kinase from liver. J. Lipid Res. 2 (1961) 235-243.

2. Levy, G.B. and Popják, G. Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver. Biochem. J. 75 (1960) 417-428.

3. Markley, K. and Smallman, E. Mevalonic kinase in rabbit liver. Biochim. Biophys. Acta 47 (1961) 327-335.

4. Tchen, T.T. Mevalonic kinase: purification and properties. J. Biol. Chem. 233 (1958) 1100-1103.

[EC 2.7.1.36 created 1961]


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