Reaction: ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
Other name(s): hydroxymethylpyrimidine kinase (phosphorylating)
Systematic name: ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
Comments: CTP, UTP and GTP can act as donors.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9026-55-5
1. Lewin, L.M. and Brown, G.M. The biosynthesis of thiamine. III. Mechanism of enzymatic formation of the pyrophosphate ester of 2-methyl-4-amino-5-hydroxymethylpyrimidine. J. Biol. Chem. 236 (1961) 2768-2771.