IUBMB Enzyme Nomenclature


Accepted name: G-protein-coupled receptor kinase

Reaction: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate

Other name(s): G protein-coupled receptor kinase; GPCR kinase; GPCRK; GRK4; GRK5; GRK6; STK16

Systematic name: ATP:[G-protein-coupled receptor] phosphotransferase

Comments: Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC, rhodopsin kinase and EC, β-adrenergic-receptor kinase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Kunapuli, P., Onorato, J.J., Hosey, M.M. and Benovic, J.L. Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. J. Biol. Chem. 269 (1994) 1099-1105. [PMID: 8288567]

2. Premont, R.T., Koch, W.J., Inglese, J. and Lefkowitz, R.J. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. J. Biol. Chem. 269 (1994) 6832-6841. [PMID: 8120045]

3. Willets, J.M., Challiss, R.A. and Nahorski, S.R. Non-visual GRKs: are we seeing the whole picture? Trends Pharmacol. Sci. 24 (2003) 626-633. [PMID: 14654303]

[EC created 2005]

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