IUBMB Enzyme Nomenclature

EC 2.7.11.28

Accepted name: tropomyosin kinase

Reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin

Other name(s): tropomyosin kinase (phosphorylating); STK

Systematic name: ATP:tropomyosin O-phosphotransferase

Comments: The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 90804-56-1

References:

1. deBelle, I. and Mak, A.S. Isolation and characterization of tropomyosin kinase from chicken embryo. Biochim. Biophys. Acta 925 (1987) 17-26. [PMID: 3593768]

2. Montgomery, K. and Mak, A.S. In vitro phosphorylation of tropomyosin by a kinase from chicken embryo. J. Biol. Chem. 259 (1984) 5555-5560. [PMID: 6325440]

3. Watson, M.H., Taneja, A.K., Hodges, R.S. and Mak, A.S. Phosphorylation of αα- and ββ-tropomyosin and synthetic peptide analogues. Biochemistry 27 (1988) 4506-4512. [PMID: 3166994]

[EC 2.7.11.28 created 1990 as EC 2.7.1.132, transferred 2005 to EC 2.7.11.28]


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