Reaction: phosphoenolpyruvate + protein histidine = pyruvate + protein Nπ-phospho-L-histidine
Other names: phosphoenolpyruvate sugar phosphotransferase enzyme I; phosphopyruvate-protein factor phosphotransferase; phosphopyruvate-protein phosphotransferase; sugar-PEP phosphotransferase enzyme I; phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase
Systematic name: phosphoenolpyruvate:protein-L-histidine Nπ-phosphotransferase
Comments: Enzyme I of the phosphotransferase system (cf. EC 220.127.116.11 protein-Nπ-phosphohistidinesugar phosphotransferase). Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. A similar reaction, where the protein is the enzyme EC 18.104.22.168 pyruvate, water dikinase, is part of the mechanism of that enzyme.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37278-17-4
1. Postma, P.W. and Roseman, S. The bacterial phosphoenolpyruvate: sugar phosphotransferase system. Biochim. Biophys. Acta 457 (1976) 213-257. [PMID: 187249]