IUBMB Enzyme Nomenclature


Accepted name: phosphomevalonate kinase

Reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate

For reaction pathway click here.

Other names: ATP:5-phosphomevalonate phosphotransferase; 5-phosphomevalonate kinase; mevalonate phosphate kinase; mevalonate-5-phosphate kinase; mevalonic acid phosphate kinase

Systematic name: ATP:(R)-5-phosphomevalonate phosphotransferase

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9026-46-4


1. Bloch, K., Chaykin, S., Phillips, A.H. and de Waard, A. Mevalonic acid pyrophosphate and isopentenyl pyrophosphate. J. Biol. Chem. 234 (1959) 2595-2604.

2. Henning, U., Möslein, E.M. and Lynen, F. Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase. Arch. Biochem. Biophys. 83 (1959) 259-267.

3. Levy, G.B. and Popják, G. Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase and phosphomevalonic kinase from liver. Biochem. J. 75 (1960) 417-428.

[EC created 1961]

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