IUBMB Enzyme Nomenclature


Accepted name: nicotinamide-nucleotide adenylyltransferase

Reaction: ATP + nicotinamide ribonucleotide = diphosphate + NAD+

For diagram of reaction click here.

Other name(s): NAD+ pyrophosphorylase; adenosine triphosphate-nicotinamide mononucleotide transadenylase; ATP:NMN adenylyltransferase; diphosphopyridine nucleotide pyrophosphorylase; nicotinamide adenine dinucleotide pyrophosphorylase; nicotinamide mononucleotide adenylyltransferase; NMN adenylyltransferase

Systematic name: ATP:nicotinamide-nucleotide adenylyltransferase

Comments: Nicotinate nucleotide can also act as acceptor. See also EC nicotinate-nucleotide adenylyltransferase.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9032-70-6


1. Atkinson, M.R., Jackson, J.F. and Morton, R.K. Nicotinamide mononucleotide adenylyltransferase of pig-liver nuclei. The effects of nicotinamide mononucleotide concentration and pH on dinucleotide synthesis. Biochem. J. 80 (1961) 318-323.

2. Dahmen, W., Webb, B. and Preiss, J. The deamido-diphosphopyridine nucleotide and diphosphopyridine nucleotide pyrophosphorylases of Escherichia coli and yeast. Arch. Biochem. Biophys. 120 (1967) 440-450. [PMID: 4291828]

3. Kornberg, A. and Pricer, W.E. Enzymatic cleavage of diphosphopyridine nucleotide with radioactive pyrophosphate. J. Biol. Chem. 191 (1951) 535-541.

[EC created 1961]

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