Reaction: nucleoside triphosphate + α-D-aldose 1-phosphate = diphosphate + NDP-hexose
Other name(s): NDP hexose pyrophosphorylase; hexose 1-phosphate nucleotidyltransferase; hexose nucleotidylating enzyme; nucleoside diphosphohexose pyrophosphorylase; hexose-1-phosphate guanylyltransferase; GTP:α-D-hexose-1-phosphate guanylyltransferase; GDP hexose pyrophosphorylase; guanosine diphosphohexose pyrophosphorylase; nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase; NTP:hexose-1-phosphate nucleotidyltransferase
Systematic name: NTP:α-D-aldose-1-phosphate nucleotidyltransferase
Comments: In decreasing order of activity, guanosine, inosine and adenosine diphosphate hexoses are substrates in the reverse reaction, with either glucose or mannose as the sugar.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37278-26-5
1. Verachtert, H., Rodriguez, P., Bass, S.T. and Hansen, R.G. Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues. J. Biol. Chem. 241 (1966) 2007-2013. [PMID: 5946626]
2. Hansen, R.G., Verachtert, H., Rodriguez, P. and Bass, S.T. GDP-hexose pyrophosphorylase from liver. Methods Enzymol. 8 (1966) 269-271.