IUBMB Enzyme Nomenclature


Accepted name: [protein-PII] uridylyltransferase

Reaction: UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII]

Other name(s): PII uridylyl-transferase; uridyl removing enzyme

Systematic name: UTP:[protein-PII] uridylyltransferase

Comments: the enzyme uridylylates and de-uridylylates the small trimeric protein PII. The enzymes from Escherichia coli and Salmonella typhimurium have been wrongly identified, in some databases, as EC (UDP-glucose—hexose-1-phosphate uridylyltransferase), from which it differs greatly in both reaction catalysed and sequence.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 57657-57-5


1. Garcia, E., Rhee, S.G. Cascade control of Escherichia coli glutamate synthetase. Purification and properties of PII uridylyltransferase and uridylyl-removing enzyme. J. Biol. Chem. 258 (1983) 2246-2253. [PMID: 6130097]

2. Van Heeswijk, W., Rabenberg, M., Westerhoff, H., Kahn, D. The genes of the glutamate synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli. Mol. Microbiol. 9 (1993) 443-457. [PMID: 8412694]

[EC created 1999]

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