IUBMB Enzyme Nomenclature


Accepted name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

For diagram click here.

Other name(s): MEP cytidylyltransferase

Systematic name: CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Comments: The enzyme from Escherichia coli requires Mg2+ or Mn2+. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 251990-59-7


1. Rohdich, F., Wungsintaweekul, J., Fellermeier, M., Sagner, S., Herz, S., Kis, K., Eisenreich, W., Bacher, A. and Zenk, M.H. Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erithritol. Proc. Natl. Acad. Sci. USA 96 (1999) 11758-11763. [PMID: 10518523]

2. Kuzuyama, T., Takagi, M., Kaneda, K., Dairi, T. and Seto, H. Formation of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway. Tetrahedron Lett. 41 (2000) 703-706.

[EC created 2001]

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