IUBMB Enzyme Nomenclature


Accepted name: GDP-D-glucose phosphorylase

Reaction: GDP-α-D-glucose + phosphate = α-D-glucose 1-phosphate + GDP

Systematic name: GDP:α-D-glucose 1-phosphate guanylyltransferase

Comments: The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-α-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Adler, L.N., Gomez, T.A., Clarke, S.G. and Linster, C.L. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. J. Biol. Chem. 286 (2011) 21511-21523. [PMID: 21507950]

[EC created 2011]

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