Reaction: ATP + GTP = 2 diphosphate + cyclic 3',5'-AMP-GMP
Glossary: cyclic 3',5'-AMP-GMP = cyclic-bis(3'→5')-AMP-GMP = 3'-guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide
Other name(s): cGAMP synthase; cGAS
Systematic name: ATP:GTP adenylyltransferase (cyclizing)
Comments: Cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Sun, L., Wu, J., Du, F., Chen, X. and Chen, Z.J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339 (2013) 786-791. [PMID: 23258413]