IUBMB Enzyme Nomenclature


Accepted name: cyclic GMP-AMP synthase

Reaction: ATP + GTP = 2 diphosphate + cyclic 3',5'-AMP-GMP

Glossary: cyclic 3',5'-AMP-GMP = cyclic-bis(3'→5')-AMP-GMP = 3'-guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide

Other name(s): cGAMP synthase; cGAS

Systematic name: ATP:GTP adenylyltransferase (cyclizing)

Comments: Cyclic 3',5'-AMP-GMP is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Sun, L., Wu, J., Du, F., Chen, X. and Chen, Z.J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339 (2013) 786-791. [PMID: 23258413]

[EC created 2013]

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