Reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine
Other name(s): phosphatidylserine synthase 2; serine-exchange enzyme II; PTDSS2 (gene name)
Systematic name: L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
Comments: This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Stone, S.J. and Vance, J.E. Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. Biochem. J. 342 (1999) 57-64. [PMID: 10432300]
2. Tomohiro, S., Kawaguti, A., Kawabe, Y., Kitada, S. and Kuge, O. Purification and characterization of human phosphatidylserine synthases 1 and 2. Biochem. J. 418 (2009) 421-429. [PMID: 19014349]