IUBMB Enzyme Nomenclature


Accepted name: tRNA sulfurtransferase

Reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide

Other names: transfer ribonucleate sulfurtransferase; RNA sulfurtransferase; ribonucleate sulfurtransferase; transfer RNA sulfurtransferase; transfer RNA thiolase

Systematic name: L-cysteine:tRNA sulfurtransferase

Comments: A group of enzymes transferring sulfur to various nucleotides in a tRNA chain, producing residues such as 4-thiouridylate. With some enzymes mercaptopyruvate can act as sulfur donor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9055-57-6


1. Abrell, J.W., Kaufman, E.E. and Lipsett, M.N. The biosynthesis of 4-thiouridylate. Separation and purification of two enzymes in the transfer ribonucleic acid-sulfurtransferase system. J. Biol. Chem. 246 (1971) 294-301. [PMID: 5541999]

2. Hayward, R.S. and Weiss, S.B. RNA thiolase: the enzymatic transfer of sulfur from cysteine to sRNA in Escherichia coli extracts. Proc. Natl. Acad. Sci. USA 55 (1966) 1161-1168. [PMID: 5334200]

3. Lipsett, M.N. and Peterkofsky, A. Enzymatic thiolation of E. coli sRNA. Proc. Natl. Acad. Sci. USA 55 (1966) 1169-1174. [PMID: 5334201]

4. Wong, T., Weiss, S.B., Eliceiri, G.L. and Bryant, J. Ribonucleic acid sulfurtransferase from Bacillus subtilis W168. Sulfuration with β-mercaptopyruvate and properties of the enzyme system. Biochemistry 9 (1970) 2376-2386. [PMID: 4987417]

[EC created 1984]

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