IUBMB Enzyme Nomenclature


Accepted name: thiosulfate—dithiol sulfurtransferase

Reaction: thiosulfate + dithioerythritol = sulfite + 4,5-cis-dihydroxy-1,2-dithiacyclohexane (i.e. oxidized dithioerythritol) + sulfide

Other name(s): thiosulfate reductase; TSR

Systematic name: thiosulfate:dithioerythritol sulfurtransferase

Comments: The enzyme from Chlorella shows very little activity towards monothiols such as glutathione and cysteine (cf. EC thiosulfate—thiolsulfurtransferase). The enzyme probably transfers the sulfur atom onto one thiol group to form -S-S-, and sulfide is spontaneously expelled from this by reaction with the other thiol group. May be identical with EC thiosulfate sulfurtransferase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9059-49-8


1. Schmidt, A., Erdle, I. and Gamon, B. Isolation and characterization of thiosulfate reductases from the green alga Chlorella fusca. Planta 162 (1984) 243-249.

[EC created 1989, modified 1999]

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