Reaction: (1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
(2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate
For diagram click here or here.
Glossary: 3'-phosphoadenylyl sulfate = PAPS
glycolithocholate sulfate = N-(3α-sulfooxy-5β-cholan-24-oyl)glycine
Other name(s): BAST I; bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase; bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase; bile acid sulfotransferase I; glycolithocholate sulfotransferase
Systematic name: 3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase
Comments: The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species . This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5β-bile acid glycolithocholate, deoxycholate, 3β-hydroxy-5-cholenoate and dehydroepiandrosterone (3β-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 188.8.131.52 (alcohol sulfotransferase) and EC 184.108.40.206 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 220.127.116.11 .
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 65802-92-8
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