IUBMB Enzyme Nomenclature

EC 2.8.2.21

Accepted name: keratan sulfotransferase

Reaction: 3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate

Glossary: 3'-phosphoadenylyl sulfate = PAPS

Other names: 3'-phosphoadenylyl keratan sulfotransferase; keratan sulfate sulfotransferase; 3'-phosphoadenylylsulfate:keratan sulfotransferase

Systematic name: 3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase

Comments: Sulfation takes place at the 6-position of galactosyl and N-acetylglucosaminyl residues in keratan, a proteoglycan. Not identical with EC 2.8.2.5 (chondroitin 4-sulfotransferase), EC 2.8.2.6 (choline sulfotransferase) or EC 2.8.2.17 (chondroitin 6-sulfotransferase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 62168-79-0

References:

1. Ruter, E.-R. and Kresse, H. Partial purification and characterization of 3'-phosphoadenylylsulfate:keratan sulfate sulfotransferases. J. Biol. Chem. 259 (1984) 11771-11776. [PMID: 6592165]

[EC 2.8.2.21 created 1989]


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