Reaction: 3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate
For diagram click here.
Glossary: 3'-phosphoadenylyl sulfate = PAPS
glycochenodeoxycholate 7-sulfate = N-(3α-hydroxy-7α-sulfooxy-5β-cholan-24-oyl)glycine
Other name(s): bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase; bile acid:PAPS:sulfotransferase; BAST
Systematic name: 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase
Comments: The enzyme specifically sulfates glycochenodeoxycholate at the 7α-position (see also EC 220.127.116.11 bile-salt sulfotransferase). The monohydroxy bile acids glycolithocholate, chenodeoxycholate and ursodeoxycholate act as inhibitors.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Barnes, S., Burhol, P.G., Zander, R., Haggstrom, G., Settine, R.L. and Hirschowitz, B.I. Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters. J. Lipid Res. 20 (1979) 952-959. [PMID: 533830]
2. Russell, D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 72 (2003) 137-174. [PMID: 12543708]