IUBMB Enzyme Nomenclature

EC 2.8.3.15

Accepted name: succinyl-CoA:(R)-benzylsuccinate CoA-transferase

Reaction: succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA

For diagram click here.

Other name(s): benzylsuccinate CoA-transferase

Systematic name: succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase

Comments: Involved in anaerobic catabolism of toluene and is a strictly toluene-induced enzyme that catalyses the reversible regio- and enantio-selective synthesis of (R)-2-benzylsuccinyl-CoA. The enzyme from Thauera aromatica is inactive when (R)-benzylsuccinate is replaced by (S)-benzylsuccinate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 260966-56-1

References:

1. Leutwein, C. and Heider, J. Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria. J. Bacteriol. 183 (2001) 4288-4295. [PMID: 11418570]

2. Leutwein, C. and Heider, J. Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and β-oxidation of the first intermediate, (R)-(+)-benzylsuccinate. Microbiology 145 (1999) 3265-3271. [PMID: 10589736]

3. Leuthner, B. and Heider, J. Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of β oxidation of the intermediate benzylsuccinate. J. Bacteriol. 182 (2000) 272-277. [PMID: 10629170]

4. Heider, J. A new familiy of CoA-transferases. FEBS Lett. 509 (2001) 345-349. [PMID: 11749953]

[EC 2.8.3.15 created 2003]


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