IUBMB Enzyme Nomenclature

EC 2.9.1.1

Accepted name: L-seryl-tRNASec selenium transferase

Reaction: L-seryl-tRNASec + selenophosphate = L-selenocysteinyl-tRNASec + phosphate

Other name(s): L-selenocysteinyl-tRNASel synthase; L-selenocysteinyl-tRNASec synthase selenocysteine synthase; cysteinyl-tRNASec-selenium transferase; cysteinyl-tRNASec-selenium transferase

Systematic name: selenophosphate:L-seryl-tRNASec selenium transferase

Comments: a pyridoxal 5'-phosphate enzyme identified in Escherichia coli. Recognises specifically tRNASec-species. Binding of tRNASec also occurs in the absence of the seryl group. 2-Aminoacryloyl-tRNA, bound to the enzyme as an imine with the pyridoxal phosphate, is an intermediate in the reaction. Since the selenium atom replaces oxygen in serine, the product may also be referred to as L-selenoseryl-tRNASec. The symbol Sel has also been used for selenocysteine but Sec is preferred.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 183869-06-9

References:

1. Forchhammer, K., Böck, A. Selenocysteine from Escherichia coli. Analysis of the reaction sequence. J. Biol. Chem. 266 (1991) 6324-6328. [PMID: 2007585]

[EC 2.9.1.1 created 1999]


Return to EC 2.9.1 home page
Return to EC 2.9 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page