IUBMB Enzyme Nomenclature


Accepted name: 6-phosphogluconolactonase

Reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate

For diagram click here.

Other name(s): phosphogluconolactonase; 6-PGL

Systematic name: 6-phospho-D-glucono-1,5-lactone lactonohydrolase

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 37278-45-8


1. Kawada, M., Kagawa, Y., Takiguchi, H. and Shimazono, N. Purification of 6-phosphogluconolactonase from rat liver and yeast; its separation from gluconolactonase. Biochim. Biophys. Acta 57 (1962) 404-407.

2. Miclet, E., Stoven, V., Michels, P.A., Opperdoes, F.R., Lallemand, J.-Y. and Duffieux, F. NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase. J. Biol. Chem. 276 (2001) 34840-34846. [PMID: 11457850]

[EC created 1972]

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