IUBMB Enzyme Nomenclature

EC 3.1.1.34

Accepted name: lipoprotein lipase

Reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate

Other name(s): clearing factor lipase; diglyceride lipase; diacylglycerol lipase; postheparin esterase; diglyceride lipase; postheparin lipase; diacylglycerol hydrolase; lipemia-clearing factor

Systematic name: triacylglycero-protein acylhydrolase

Comments: Hydrolyses triacylglycerols in chylomicrons and low-density lipoproteins. Also hydrolyses diacylglycerol.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9004-02-8

References:

1. Egelrud, T. and Olivecrona, T. Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors. Biochim. Biophys. Acta 306 (1973) 115-127. [PMID: 4703566]

2. Fielding, C.J. Human lipoprotein lipase. I. Purification and substrate specificity. Biochim. Biophys. Acta 206 (1970) 109-117. [PMID: 5441398]

3. Greten, H., Levy, R.I., Fales, H. and Fredrickson, D.S. Hydrolysis of diglyceride and glyceryl monoester diethers with lipoprotein lipase. Biochim. Biophys. Acta 210 (1970) 39-45. [PMID: 5466051]

4. Morley, N. and Kuksis, A. Positional specificity of lipoprotein lipase. J. Biol. Chem. 247 (1972) 6389-6393. [PMID: 5076762]

5. Nilsson-Ehle, P., Belfrage, P. and Borgström, B. Purified human lipoprotein lipase: positional specificity. Biochim. Biophys. Acta 248 (1971) 114-120. [PMID: 5168777]

[EC 3.1.1.34 created 1972, modified 1976]


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