IUBMB Enzyme Nomenclature


Accepted name: sialate O-acetylesterase

Reaction: N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate

Other name(s): N-acetylneuraminate acetyltransferase; sialate 9(4)-O-acetylesterase; sialidase

Systematic name: N-acyl-O-acetylneuraminate O-acetylhydrolase

Comments: Acts on free and glycosidically bound N-acetyl- or N-glycoloyl-neuraminic acid; acts mainly on the 4-O- and 9-O-acetyl groups. Also acts on some other O-acetyl esters, both cyclic and acyclic compounds, which are not sialic acids.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 89400-31-7


1. Garcia-Sastre, A., Villar, E., Manuguerra, J.C., Hannoun, C. and Cabezas, J.A. Activity of influenza C virus O-acetylesterase with O-acetyl-containing compounds. Biochem. J. 273 (1991) 435-441. [PMID: 1991039]

2. Shukla, A.K. and Schauer, R. High performance liquid chromatography of enzymes of sialic acid metabolism. Hoppe-Seyler's Z. Physiol. Chem. 363 (1982) 1039-1040.

[EC created 1984]

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