IUBMB Enzyme Nomenclature


Accepted name: protein phosphatase methylesterase-1

Reaction: [phosphatase 2A protein]-leucine methyl ester + H2O = [phosphatase 2A protein]-leucine + methanol

Other name(s): PME-1; PPME1

Systematic name: [phosphatase 2A protein]-leucine ester acylhydrolase

Comments: A key regulator of protein phosphatase 2A. The methyl ester is formed by EC (leucine carboxy methyltransferase-1). Occurs mainly in the nucleus.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Ogris, E., Du, X., Nelson, K.C., Mak, E.K., Yu, X.X., Lane, W.S. and Pallas, D.C. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. J. Biol. Chem. 274 (1999) 14382-14391. [PMID: 10318862]

2. Xing, Y., Li, Z., Chen, Y., Stock, J.B., Jeffrey, P.D. and Shi, Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell 133 (2008) 154-163. [PMID: 18394995]

[EC created 2011]

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