IUBMB Enzyme Nomenclature


Accepted name: exodeoxyribonuclease (lambda-induced)

Reaction: Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates

Other name(s): lambda exonuclease; phage lambda-induced exonuclease; Escherichia coli exonuclease IV; E. coli exonuclease IV; exodeoxyribonuclease IV; exonuclease IV

Comments: Preference for double-stranded DNA. Does not attack single-strand breaks. Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37367-70-7


1. Lindahl, T., Gally, J.A. and Edelman, G.M. Deoxyribonuclease IV: a new exonuclease from mammalian tissues. Proc. Natl. Acad. Sci. USA 62 (1969) 597-603. [PMID: 5256235]

2. Little, J.W. An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction. J. Biol. Chem. 242 (1967) 679-686. [PMID: 6017737]

[EC created 1972 as EC, transferred 1978 to EC]

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