IUBMB Enzyme Nomenclature

EC 3.1.2.12

Accepted name: S-formylglutathione hydrolase

Reaction: S-formylglutathione + H2O = glutathione + formate

Systematic name: S-formylglutathione hydrolase

Comments: Also hydrolyses S-acetylglutathione, but more slowly.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 83380-83-0

References:

1. Uotila, L. Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases. Biochemistry 12 (1973) 3938-3943. [PMID: 4200890]

2. Uotila, L. and Koivusalo, M. Purification and properties of S-formylglutathione hydrolase from human liver. J. Biol. Chem. 249 (1974) 7664-7672. [PMID: 4436331]

3. Harms, N., Ras, J., Reijnders, W.N., van Spanning, R.J. and Stouthamer, A.H. S-Formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification? J. Bacteriol. 178 (1996) 6296-6299. [PMID: 8892832]

[EC 3.1.2.12 created 1978]


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