IUBMB Enzyme Nomenclature

EC 3.1.2.15

Accepted name: ubiquitin thiolesterase

Reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol

Other name(s): ubiquitin carboxy-terminal esterase; isopeptidase (misleading); isopeptidase T (misleading); ubiquitin C-terminal hydrolase; ubiquitin carboxy-terminal hydrolase; ubiquitin-C-terminal-thiolester hydrolase

Systematic name: ubiquitin-C-terminal-thioester hydrolase

Comments: Acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin. May be the same as EC 3.4.19.12, ubiquitinyl hydrolase 1.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 86480-67-3

References:

1. Rose, I.A. and Warms, J.V.B. An enzyme with ubiquitin carboxy-terminal esterase activity from reticulocytes. Biochemistry 22 (1983) 4234-4237. [PMID: 6313036]

[EC 3.1.2.15 created 1986]


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