IUBMB Enzyme Nomenclature


Accepted name: palmitoyl[protein] hydrolase

Reaction: palmitoyl[protein] + H2O = palmitate + protein

Other name(s): palmitoyl-protein thioesterase; palmitoyl-(protein) hydrolase

Systematic name: palmitoyl[protein] hydrolase

Comments: specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 150605-49-5


1. Camp, L.A., Hofmann, S.L. Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate. Methods Enzymol. 250 (1995) 336-347. [PMID: 7651163]

2. Schriner, J.E., Yi, W., Hofmann, S.L. cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis. Genomics, 34 (1996) 317-322. [PMID: 8786130]

3. Verkruyse, L.A., Hofmann, S.L. Lysosomal targeting of palmitoyl-protein thioesterase. J. Biol. Chem. 271 (1996) 15831-15836. [PMID: 8663305]

[EC created 1999]

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