IUBMB Enzyme Nomenclature

EC 3.1.2.26

Accepted name: bile-acid-CoA hydrolase

Reaction: deoxycholoyl-CoA + H2O = CoA + deoxycholate

Glossary: deoxycholate = 3α,12α-dihydroxy-5β-cholan-24-oate

Systematic name: deoxycholoyl-CoA hydrolase

Comments: Choloyl-CoA, 3-dehydrocholoyl-CoA and chenodeoxycholoyl-CoA can also act as substrates, but acetyl-CoA, isovaleryl-CoA, palmitoyl-CoA and phenylacetyl-CoA cannot.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 220983-07-3

References:

1. Ye, H.Q., Mallonee, D.H., Wells, J.E., Bjorkhem, I. and Hylemon, P.B. The bile acid-inducible baiF gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A hydrolase. J. Lipid Res. 40 (1999) 17-23. [PMID: 9869646]

[EC 3.1.2.26 created 2005]


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