IUBMB Enzyme Nomenclature

EC 3.1.21.2

Accepted name: deoxyribonuclease IV (phage-T4-induced)

Reaction: Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products

Other name(s): endodeoxyribonuclease IV (phage T4-induced); E. coli endonuclease IV; endodeoxyribonuclease; redoxyendonuclease; deoxriboendonuclease; Escherichia coli endonuclease II; endonuclease II; DNA-adenine-transferase

Comments: Preference for single-stranded DNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 63363-78-0

References:

1. Friedberg, E.C. and Goldthwait, D.A. Endonuclease II of E. coli. I. Isolation and purification. Proc. Natl. Acad. Sci. USA 62 (1969) 934-940. [PMID: 4895219]

2. Friedberg, E.C., Hadi, S.-M. and Goldthwait, D.A. Endonuclease II of Escherichia coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid. J. Biol. Chem. 244 (1969) 5879-5889. [PMID: 4981786]

3. Hadi, S.M. and Goldthwait, D.A. Endonuclease II of Escherichia coli. Degradation of partially depurinated deoxyribonucleic acid. Biochemistry 10 (1971) 4986-4993. [PMID: 4944066]

4. Sadowski, P.D. and Hurwitz, J. Enzymatic breakage of deoxyribonucleic acid. I. Purification and properties of endonuclease II from T4 phage-infected Escherichia coli. J. Biol. Chem. 244 (1969) 6182-6191. [PMID: 4310836]

[EC 3.1.21.2 created 1972 as EC 3.1.4.30, transferred 1978 to EC 3.1.21.2]


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