IUBMB Enzyme Nomenclature


Accepted name: ribonuclease H

Reaction: Endonucleolytic cleavage to 5'-phosphomonoester

Other name(s): endoribonuclease H (calf thymus); RNase H; RNA*DNA hybrid ribonucleotidohydrolase; hybrid ribonuclease; hybridase; hybridase (ribonuclease H); ribonuclease H; hybrid nuclease; calf thymus ribonuclease H

Comments: Acts on RNA-DNA hybrids.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9050-76-4


1. Haberkern, R.C. and Cantoni, G.L. Studies on a calf thymus ribonuclease specific for ribonucleic acid-deoxyribonucleic acid hybrids. Biochemistry 12 (1973) 2389-2395. [PMID: 4709937]

2. Stavrianopoulos, J.G. and Chargaff, E. Purification and properties of ribonuclease H of calf thymus. Proc. Natl. Acad. Sci. USA 70 (1973) 1959-1963. [PMID: 4516197]

[EC created 1978, modified 2010]

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