Reaction: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates
Other name(s): RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase
Comments: Formerly EC 220.127.116.11 and EC 18.104.22.168.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9001-99-4
1. Anfinsen, C.B. and White, F.H., Jr. The ribonucleases: occurrence, structure, and properties, in Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 5, Academic Press, New York, 1961, pp. 95-122.
2. Beard, J.R. and Razzell, W.E. Purification of alkaline ribonuclease II from mitochondrial and soluble fractions of liver. J. Biol. Chem. 239 (1964) 4186-4193.
3. Cannistraro, V.J. and Kennell, D. Purification and characterization of ribonuclease M and mRNA degradation in Escherichia coli. Int. J. Biochem. 181 (1989) 363-370.