IUBMB Enzyme Nomenclature


Accepted name: alkaline phosphatase

Reaction: A phosphate monoester + H2O = an alcohol + phosphate

Other name(s): alkaline phosphomonoesterase; phosphomonoesterase; glycerophosphatase; alkaline phosphohydrolase; alkaline phenyl phosphatase; orthophosphoric-monoester phosphohydrolase (alkaline optimum)

Systematic name: phosphate-monoester phosphohydrolase (alkaline optimum)

Comments: Wide specificity. Also catalyses transphosphorylations. The human placental enzyme is a zinc protein. Some enzymes hydrolyse diphosphate (cf. EC inorganic diphosphatase)

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9001-78-9


1. Engström, L. Studies on calf-intestinal alkaline phosphatase. I. Chromatographic purification, microheterogeneity and some other properties of the purified enzyme. Biochim. Biophys. Acta 52 (1961) 36-48.

2. Harkness, D.R. Studies on human placental alkaline phosphatase. II. Kinetic properties and studies on the apoenzyme. Arch. Biochem. Biophys. 126 (1968) 513-523. [PMID: 4970479]

3. Malamy, M.H. and Horecker, B.L. Purification and crystallization of the alkaline phosphatase of Escherichia coli. Biochemistry 3 (1964) 1893-1897.

4. Morton, R.K. Alkaline phosphatase of milk. 2. Purification of the enzyme.Biochem. J. 55 (1953) 795-800.

5. Stadtman, T.C. Alkaline phosphatases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 5, Academic Press, New York, 1961, pp. 55-71.

[EC created 1961]

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