IUBMB Enzyme Nomenclature


Accepted name: polynucleotide 3'-phosphatase

Reaction: A 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate

Other name(s): 2'(3')-polynucleotidase; DNA 3'-phosphatase; deoxyribonucleate 3'-phosphatase; 5'-polynucleotidekinase 3'-phosphatase

Systematic name: polynucleotide 3'-phosphohydrolase

Comments: Also hydrolyses nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37288-16-7


1. Becker, A. and Hurwitz, J. The enzymatic cleavage of phosphate termini from polynucleotides. J. Biol. Chem. 242 (1967) 936-950. [PMID: 4289819]

[EC created 1972]

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