IUBMB Enzyme Nomenclature


Accepted name: 5'-nucleotidase

Reaction: A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate

Other name(s): uridine 5'-nucleotidase; 5'-adenylic phosphatase; adenosine 5'-phosphatase; AMP phosphatase; adenosine monophosphatase; 5'-mononucleotidase; AMPase; UMPase; snake venom 5'-nucleotidase; thimidine monophosphate nucleotidase; 5'-AMPase; 5'-AMP nucleotidase; AMP phosphohydrolase; IMP 5'-nucleotidase

Systematic name: 5'-ribonucleotide phosphohydrolase

Comments: Wide specificity for 5'-nucleotides.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9027-73-0


1. Gulland, J.M. and Jackson, E.M. 5-Nucleotidase. Biochem. J. 32 (1938) 597-601.

2. Heppel, L.A. and Hilmoe, R.J. Purification and properties of 5-nucleotidase. J. Biol. Chem. 188 (1951) 665-676.

3. Segal, H.L. and Brenner, B.M. 5'-Nucleotidase of rat liver microsomes. J. Biol. Chem. 235 (1960) 471-474.

[EC created 1961]

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