IUBMB Enzyme Nomenclature


Accepted name: 3'(2'),5'-bisphosphate nucleotidase

Reaction: adenosine 3',5'-bisphosphate + H2O = AMP + phosphate

Other name(s): phosphoadenylate 3'-nucleotidase; 3'-phosphoadenylylsulfate 3'-phosphatase; phosphoadenylate 3'-nucleotidase; 3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase

Systematic name: adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase

Comments: Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9025-83-6


1. Brungraber, E.G. Nucleotides involved in the enzymatic conjugation of phenols with sulfate. J. Biol. Chem. 233 (1958) 472-477.

2. Farooqui, A.A. and Balasubramanian, A.S. Enzymatic dephosphorylation 3'-phosphoadenosine 5'-phosphosulfate to adenosine 5'-phosphosulfate in sheep brain. Biochim. Biophys. Acta 198 (1970) 56-65. [PMID: 4313079]

3. Ramaswamy, S.G. and Jakoby, W.B. (2')3',5'-Bisphosphate nucleotidase. J. Biol. Chem. 262 (1987) 10044-10047. [PMID: 3038862]

4. Tsang, M. L.-S. and Schiff, J.A. Properties of enzyme fraction A from Chlorella and copurification of 3' (2'), 5'-biphosphonucleoside 3' (2')-phosphohydrolase, adenosine 5'phosphosulfate sulfohydrolase and adenosine-5'-phosphosulfate cyclase activities. Eur. J. Biochem. 65 (1976) 113-121. [PMID: 179817]

[EC created 1961]

Return to EC 3.1.3 home page
Return to EC 3.1 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page