IUBMB Enzyme Nomenclature


Accepted name: 2-phosphosulfolactate phosphatase

Reaction: (2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate

For diagram of reaction click here

Other name(s): (2R)-phosphosulfolactate phosphohydrolase; ComB phosphatase

Systematic name: (R)-2-phospho-3-sulfolactate phosphohydrolase

Comments: Requires Mg2+. The enzyme from Methanococcus jannaschii acts on both stereoisoimers of the substrate and also hydrolyses a number of phosphate monoesters of (S)-2-hydroxycarboxylic acids, including 2-phosphomalate, 2-phospholactate and 2-phosphoglycolate. This enzyme can also hydrolyze phosphate monoesters of (R)-2-hydroxycarboxylic acids such as (S)-2-phospho-3-sulfolactate and (R)-2-phosphomalate, which, presumably, bind to the enzyme in opposite orientations.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 409095-18-7


1. Graham, D.E., Graupner, M., Xu, H. and White, R.H. Identification of coenzyme M biosynthetic 2-phosphosulfolactate phosphatase. Eur. J. Biochem. 268 (2001) 5176-5188. [PMID: 11589710]

[EC created 2002]

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